Emerging data alludes that fisetin may be supportive for health promotion and chronic disease prevention, helping to optimize cellular functioning, cardiovascular health, neuroprotection, and more. This article explains:

• • Key facts about fisetin and its beneficial effects;
  • How to add fisetin to your functional treatment plan;
  • Info about our integrative treatment approach to healthcare. 

What is Fisetin? 

Flavonoids are natural compounds sourced from vegetables, fruits, bark, grains, roots and flowers. Strawberries, apples, persimmons, and onions contain fisetin, which is a specific type of flavonoid. 

Fisetin has been applauded for its promising effects on longevity, reducing inflammation, and defending against neurodegeneration. Due to its protective effects against cellular damage, it has the potential to improve quality of life. Here are some additional facts to note about the flavonoid: 

• • Fisetin is naturally anti-inflammatory. “Chronic inflammation is a prolonged and dysregulated immune response leading to a wide variety of physiological and pathological conditions such as neurological abnormalities, cardiovascular diseases, diabetes, obesity, pulmonary diseases, immunological diseases, cancers, and other life-threatening conditions,” confirms an article from Advances in Experimental Medicine and Biology. However, studies have shown fisetin to naturally inhibit pro-inflammatory cytokines, which can help with diminishing systemic inflammation. 
  • It may contain anti-cancer properties. The nutrient has the potential to trigger apoptosis in cancer cells without harming healthy cells; it may also suppress the spread of tumors. 
  • Fisetin may offer neuroprotective effects. It may reduce amyloid beta levels in the brain, which are toxic protein aggregates linked to Alzheimer’s disease; in turn, fisetin may contribute to improving synaptic function and memory.
  • The flavonoid may be beneficial for combating oxidative stress. When the ratio of free radicals is higher than the number of antioxidants in your body, oxidative stress ensues. Fisetin can reduce these levels to prevent cell and tissue damages. 
  • Cardiovascular health improvements may result from this supplement. The nutrient is thought to improve lipid profiles and lessen blood pressure levels.
  • It may contribute to aging gracefully and extending the lifespan. Fisetin is one of the few natural compounds known as a senolytic agent, meaning it can selectively destroy senescent cells. These “zombie cells” accumulate with age and contribute to chronic inflammation. Scientists also posit that fisetin may improve tissue function, potentially extending the lifespan. 
  • Fisetin can also boost your amounts of glutathione. Fisetin can help increase glutathione levels in the body. When glutathione is increased, it can help boost collagen production to promote a youthful appearance. 

If you’re interested in this supplement, it may be beneficial to consult with your healthcare providers first, such as a functional-practicing naturopathic doctor. We explain why in the next section. 

Suggested Reading: What is Cat’s Claw? A Functional Medicine Toronto Fact Sheet

The Role of Functional Medicine Therapies

Therapies adapted under the functional medicine model can help target widespread symptoms that are unique to your biology only. Here’s how:

• • Extensive testing is offered, which can provide details that conventional tests may not be able to capture.  
  • Select supplements, such as IV therapy drips, are uniquely dosed to match your personal health goals.  
  • Ample health education to patients is provided to improve confidence, especially for adhering to lifestyle modifications.  

It’s recommended to seek formal health advice before consuming new supplements – this is especially important for avoiding interactions with prescription medications. Fisetin, for instance, is a nourishing and natural constituent, though it may interact with blood thinners. You’re welcome to contact our clinic to see if this antioxidant suits your current health condition.  

About Our Integrated Health Care 

Inside our Toronto area functional medicine clinic, we embrace an integrative treatment approach to wellness. What this means is that a treatment plan from us can contain several modalities adapted for your biology. Our clinicians are adept at customizing a wide variety of treatment options, integrating conventional healthcare with natural therapies (i.e. naturopathic medicine and homeopathic medicine), psychotherapy, botanical supplementation, detoxification and hormone optimization programs, intravenous drips, and more.

Integrative functional medicine strategies are suitable for managing a wide variety of health issues; examples include digestive issues, athletic recovery, weakened immune function, lack of energy (chronic fatigue syndrome), premature aging, and more. These treatments offer inclusive care that recognizes mind-and-body needs, helping patients inherently with their optimal health outcomes. 

If you’re ready to take charge of your health condition with lifestyle modifications, nutrition, lab testing, and more, we invite you to become a new patient today!

How can we help you achieve optimal health outcomes? Discover the benefits of a tailored treatment plan – click here to call the Toronto Functional Medicine Centre to request your initial session. 

Disclaimer: The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. You should always consult with a health care practitioner before relying on any information in this article or on this website. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of information you have read from the Toronto Functional Medicine Centre website or other affiliate media. 

 

References

Chen, T., Feng, Y., Liu, T., Wu, T., Chen, Y., Li, X., Li, Q., & Wu, Y. (2020). Fisetin Regulates Gut Microbiota and Exerts Neuroprotective Effect on Mouse Model of Parkinson’s Disease. Frontiers in Neuroscience, 14, 549037. https://doi.org/10.3389/fnins.2020.549037

Domaszewska-Szostek A, Puzianowska-Kuźnicka M, Kuryłowicz A. Flavonoids in Skin Senescence Prevention and Treatment. Int J Mol Sci. 2021 Jun 25;22(13):6814. doi: 10.3390/ijms22136814. PMID: 34201952; PMCID: PMC8267725.

Jiang, K., Yang, J., Xue, G., Dai, A., & Wu, H. (2021). Fisetin Ameliorates the Inflammation and Oxidative Stress in Lipopolysaccharide-Induced Endometritis. Journal of Inflammation Research, 14, 2963. https://doi.org/10.2147/JIR.S314130

Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: A Dietary Antioxidant for Health Promotion. Antioxidants & Redox Signaling, 19(2), 151. https://doi.org/10.1089/ars.2012.4901

Nabizadeh, Z., Nasrollahzadeh, M., Shabani, A. A., Mirmohammadkhani, M., & Nasrabadi, D. (2023). Evaluation of the anti-inflammatory activity of fisetin-loaded nanoparticles in an in vitro model of osteoarthritis. Scientific Reports, 13, 15494. https://doi.org/10.1038/s41598-023-42844-1

Ortolá R, García-Esquinas E, García-Varela G, Struijk EA, Rodríguez-Artalejo F, López-García E. Influence of Changes in Diet Quality on Unhealthy Aging: The Seniors-ENRICA Cohort. Am J Med. 2019 Sep;132(9):1091-1102.e9. doi: 10.1016/j.amjmed.2019.03.023. Epub 2019 Apr 11. PMID: 30981558.

Pal HC, Pearlman RL, Afaq F. Fisetin and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:213-244. doi: 10.1007/978-3-319-41334-1_10. PMID: 27671819.

Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016). Flavonoids: An overview. Journal of Nutritional Science, 5, e47. https://doi.org/10.1017/jns.2016.41

Rodius S, de Klein N, Jeanty C, Sánchez-Iranzo H, Crespo I, Ibberson M, Xenarios I, Dittmar G, Mercader N, Niclou SP, Azuaje F. Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity. Sci Rep. 2020 Feb 19;10(1):2896. doi: 10.1038/s41598-020-59894-4. PMID: 32076073; PMCID: PMC7031222.

Tavenier, J., Nehlin, J. O., Houlind, M. B., Rasmussen, L. J., Tchkonia, T., Kirkland, J. L., Andersen, O., & Rasmussen, L. J. H. (2024). Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases. Mechanisms of Ageing and Development, 222, 111995. https://doi.org/10.1016/j.mad.2024.111995

Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan.