Did you know declining NAD levels can affect testosterone, energy levels, and athleticism in men? NAD IV therapy from the Toronto Functional Medicine Centre may be useful for males struggling with these health concerns. 

Studies have proven that NAD serum amounts decline when men reach middle age. This can be concerning, as low NAD has been linked to age-related issues, such as poor muscle function, excessive inflammation, and lifespan reduction. “Additionally, numerous diseases are associated with reduced NAD+ levels, including metabolic disorders, cancer, and neurodegenerative diseases,” states a report from The Journals of Gerontology Series A: Biological Sciences and Medical Sciences.

Men with various health goals – including fertility and sports training – may consider this coenzyme for its potential beneficial effects. Our functional medicine clinic brings attention to: 

• • What exactly NAD is;
  • How this supplement may bear significance for men to age gracefully;
  • Details about our NAD+ IV therapy treatments. 

Quick Recap: What is Nicotinamide Adenine Dinucleotide (NAD)?

NAD is a crucial coenzyme that revs our cellular functions, ensuring that metabolic chemical reactions take place. NAD has a vital role in assisting several bodily functions, and ideal amounts may help foster: 

• • DNA repair 
  • Anti-aging effects (i.e. preventing degenerative diseases)
  • Cognitive function
  • Blood sugar regulation
  • Immune function
  • Anti-inflammatory functions
  • Skeletal muscle and cardiovascular health 

Scientists have concluded that declining amounts can impact mental and physiological functions, potentially contributing to ‘low T’ (low testosterone), poor cellular energy production, and weakened tissue repair in men. 

NAD+ IV Therapy Health Benefits for Aging Men

When this coenzyme is taken as a supplement (i.e. via intravenous therapy or capsules), it may help men deal with inflammation, brain function, muscle repair, and conception. These are all factors that can subside from a NAD deficiency. Here are some examples of how NAD may be beneficial for males: 

• • It shows promise in promoting tissue repair. Optimizing cellular health may improve how your body heals from injuries. Increasing NAD directly affects you on a cellular level, enhancing your body’s protein synthesis. In turn, tissue growth and repair may improve, helping you to recover from aches. 

• • May potentially help enhance strength. In the aging body, studies show that NAD significantly wanes in the skeletal muscle. This can negatively affect men, as NAD has a key role in optimizing energy metabolism and mitochondrial function for high-endurance sports. With that, NAD may be beneficial if your speed and strength are not up to par as the ‘good ol’ days’. 
  • Appears to lessen inflammation. Cellular damage from oxidative stress can be detrimental to the tissues, possibly triggering inflammation. NAD naturally protects the body from oxidative stress, so supplementation may benefit chronic inflammation and injury recovery.  
  • May support testosterone regulation. Starting in their 30s or 40s, testosterone declines by 1% per year in the male body. This may not only affect fertility, but also libido, sleep, and concentration levels. NAD might help boost testosterone not through the reproductive organs directly, but via the pituitary gland. This can encourage the release of the luteinizing hormone, which then activates the testes to generate more testosterone.  

• • Might contribute to positive effects for fertility. According to a report from Reproduction (Cambridge, England), “The age of first-time parents … has significantly risen in recent years, a delay that has been coupled to increased infertility problems…” Lacking NAD due to aging can hinder testicular functions, which may lower sperm count, quality, and DNA integrity. With that, exploring opportunities to boost NAD may help with conception results. 

If you’ve reached a fitness plateau or you’re having issues managing pain, sperm health, or chronic fatigue, why not check out NAD? There are various ways to take this essential coenzyme, which include oral, sublingual or intravenous routes. Request your consult with us to learn more. 

Suggested reading: What to Pair with NAD IV Therapy in Toronto: Top 6 IV Nutrient Add-Ons

New Patients are Welcome at the Toronto Functional Medicine Centre

If you’ve been suffering from health obstacles, we can support your healing potential! Each wellness journey is a unique experience – treatments for your health may not necessarily apply to another patient’s needs. Our functional medicine practitioners are adept at customizing treatment plans for your biology only!

NAD+ IV drip therapy can be prescribed by our IV therapists. The process to get it requires attending an initial visit, which will involve discussing your health goals, lifestyle, environmental exposures, etc. If NAD is appropriate for you, a dosage will be tailored with the principles of functional medicine. You can receive your IV drip immediately after your first visit or book it for another day. 

NAD intravenous therapy is administered in our IV Lounge, which is conveniently inside our clinic. In here, IV drip therapy is blended daily without added preservatives, which means you’re guaranteed a fresh and natural vitamin infusion. Each IV therapy session is closely overseen by our health team of naturopathic doctors, nurse practitioners, and registered nurses. 

Take note: Nutritional and NAD+ IV therapy has the potential to promote beneficial effects for general needs (i.e. improving cellular repair and skin health, alleviating mineral deficiencies, and managing chronic stress). But keep in mind, IV nutrient drips are not a substitute for healthy habits (i.e. a balanced diet and regular exercise). They’re administered as adjuvant therapies by our clinic, and may be supportive when combined with functional therapies and lifestyle modifications. 

Need a game changer for your athletic performances? NAD IV therapy from the Toronto Functional Medicine Centre is now available for new patients! Request your initial consultation by clicking here, and we’ll respond to you shortly.

Disclaimer: The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. You should always consult with a health care practitioner before relying on any information in this article or on this website. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of information you have read from the Toronto Functional Medicine Centre website or other affiliate media. 

 

References

Abdellatif M, Sedej S, Kroemer G. NAD+ Metabolism in Cardiac Health, Aging, and Disease. Circulation. 2021 Nov 30;144(22):1795-1817. doi: 10.1161/CIRCULATIONAHA.121.056589. Epub 2021 Nov 29. PMID: 34843394.

Bai X, Wang P. Relationship between sperm NAD + concentration and reproductive aging in normozoospermia men:A Cohort study. BMC Urol. 2022 Oct 1;22(1):159. doi: 10.1186/s12894-022-01107-3. PMID: 36182928; PMCID: PMC9526896.

Campelj, D., & Philp, A. (2022). NAD+ Therapeutics and Skeletal Muscle Adaptation to Exercise in Humans. Sports Medicine (Auckland, N.z.), 52(Suppl 1), 91. https://doi.org/10.1007/s40279-022-01772-2

Chubanava, S., & Treebak, J. T. (2023). Regular exercise effectively protects against the aging-associated decline in skeletal muscle NAD content. Experimental Gerontology, 173, 112109. https://doi.org/10.1016/j.exger.2023.112109

Dolopikou, C.F., Kourtzidis, I.A., Margaritelis, N.V. et al. Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study. Eur J Nutr 59, 505–515 (2020). https://doi.org/10.1007/s00394-019-01919-4

Feuz, M. B., Nelson, D. C., Miller, L. B., Zwerdling, A. E., Meyer, R. G., & Meyer-Ficca, M. L. (2024). Current Insights & a Potential Role of NAD in the Reproductive Health of Aging Fathers and Their Children. Reproduction (Cambridge, England), 167(6), e230486. https://doi.org/10.1530/REP-23-0486

Freeberg, K. A., Udovich, C. C., Martens, C. R., Seals, D. R., & Craighead, D. H. (2023). Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 78(12), 2435. https://doi.org/10.1093/gerona/glad106

Migliavacca E, Tay SKH, Patel HP, Sonntag T, Civiletto G, McFarlane C, Forrester T, Barton SJ, Leow MK, Antoun E, Charpagne A, Seng Chong Y, Descombes P, Feng L, Francis-Emmanuel P, Garratt ES, Giner MP, Green CO, Karaz S, Kothandaraman N, Marquis J, Metairon S, Moco S, Nelson G, Ngo S, Pleasants T, Raymond F, Sayer AA, Ming Sim C, Slater-Jefferies J, Syddall HE, Fang Tan P, Titcombe P, Vaz C, Westbury LD, Wong G, Yonghui W, Cooper C, Sheppard A, Godfrey KM, Lillycrop KA, Karnani N, Feige JN. Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities. Nat Commun. 2019 Dec 20;10(1):5808. doi: 10.1038/s41467-019-13694-1. PMID: 31862890; PMCID: PMC6925228.

Navas, L. E., & Carnero, A. (2021). NAD+ metabolism, stemness, the immune response, and cancer. Signal Transduction and Targeted Therapy, 6(1), 1-20. https://doi.org/10.1038/s41392-020-00354-w

Poljsak B, Milisav I. NAD+ as the Link Between Oxidative Stress, Inflammation, Caloric Restriction, Exercise, DNA Repair, Longevity, and Health Span. Rejuvenation Res. 2016 Oct;19(5):406-415. doi: 10.1089/rej.2015.1767. Epub 2016 Mar 16. PMID: 26725653.

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