Aging cannot be cured – but some nutraceuticals, including NAD IV therapy from Toronto, may contribute to delaying or preventing age-related health concerns. 

Several studies state that positive daily habits – including exercise, a Mediterranean-based diet, and reduced exposures to pollutants – are crucial for preventing early skin and brain aging. But there’s a problem – living in the Western world exposes us to smog, chronic stress, preservatives, and a lack of sleep! Sometimes it feels as though crow’s feet and brain fog are inevitable. But there is potential in taking actions to reduce aging results; and some oral supplements and IV therapy treatments may promote beneficial effects. 

In our Toronto IV Lounge, we tailor treatment plans to support healthy aging goals with integrative functional medicine. We highlight our supplement recommendations below – they may even inspire you to work towards healthy longevity!

List of Anti-Aging Supplements to Consider

The following supplements may not apply to every patient, as each person has a unique biology. These supplements, however, can be part of functional treatment plans if they suit your needs; they may contribute to improving cellular functions, skin vitality, DNA repair, brain function, and the prevention/slowdown of age-related diseases. 

• • NAD+ IV therapy and precursors: Nicotinamide adenine dinucleotide (NAD) is a coenzyme that naturally wanes with aging; this decline has been linked to the formation of age-related cognitive decline, muscle frailty, cellular damage, and degenerative diseases. Scientists postulate that optimal NAD levels in the body may extend the human lifespan. Replenishing NAD levels can be achieved with NAD IV therapy drips or oral supplements that contain NAD precursors, such as nicotinamide mononucleotide (NMN).
  • Resveratrol: Found in grapes and peanuts, this is a type of polyphenol that may foster beneficial effects on cellular processes: “… many studies highlighted [resveratrol’s] importance in aging treatment through suppressing oxidative stress, inhibiting inflammatory response, improving mitochondrial function, and modulating apoptosis,” explains an Oxidative Medicine and Cellular Longevity article. There’s another health benefit to taking resveratrol: it’s a precursor to NAD, so this supplementation could also help boost NAD levels.
  • Ergothioneine: This group of amino acids contains potent antioxidant effects; it’s found in mushrooms, tempeh, and oat bran. Lab reports have demonstrated that low amounts of ergothioneine in humans are related to poor cardiovascular health, cognitive impairments, and the formation of cataracts. Studies have proven though that this nutrient has the ability to scavenge free radicals, which can delay or prevent wrinkles, weakness and cognitive decline. Furthermore, ergothioneine may support health benefits on a cellular level: “EGT is a promising candidate to protect mitochondria and eliminate cell senescence which is the denominator of the ageing process,” confirms an Experimental Gerontology piece. 
  • Fisetin: Supplementing with this flavanol may also improve cell health by subsiding senescent cells. These cells can form with aging, and instead of multiplying and dying off, they live in the body and continuously release inflammatory chemicals. Fisetin may also help regulate your body’s collection of fat cells; its supplementation may reduce the stimulation of mTor, a type of protein affiliated with age-related weight gain. 
  • Spermidine: This is a nutrient found in soy products, corn, whole grains, mushrooms, and aged cheese, and it contains anti-inflammatory, neuroprotective, and anti-cancer properties. Just like NAD, studies have shown that spermidine in the human body diminishes with aging. Along with exercise, taking this supplement may help prevent mitochondrial dysfunction and foster anti-aging effects linked to memory and liver health.   

A note about taking anti-aging supplements

Supplements have a key role in supporting optimal health, especially as people age! But when do you begin taking anti-aging supplements? This calls for a discussion between yourself and your health care practitioner, as aging affects us differently. 

Consulting with a health care provider is needed before taking new supplements or adopting health regimes. We hold various genes and lifestyles, and environmental factors affect people uniquely. Dietary and nutrition needs range between individuals, too; some people may have nutritional deficiencies that affect their muscle health, energy levels, and mental clarity. Also, the absorption rate of nutrients contrasts between individuals. Thus, a functional health care practitioner may be ideal for tailoring treatment plans, while considering the key components of your individuality (i.e. medication interactions). For anti-aging purposes, IV NAD+ drips can be prescribed in our Toronto IV Lounge – details are below. For athletes, it may interest you to check our previous post on the role of NAD IV therapy in Toronto for athletes.

How to Get NAD+ IV Therapy at the Toronto Functional Medicine Centre (TFMC)

If you’re interested in getting NAD IV+ drip treatments, we ask that you attend an initial consultation with our IV therapy providers. This session is mandatory for tailoring your NAD dose! We’ll be discussing your family/medical history, lifestyle, and more to get a glimpse of your needs. This is an ideal time to open up about your health goals, too – whether it’s to promote an improvement in energy levels or upgrade physical and mental performance, we take these into consideration while customizing your treatment plan. (Functional medicine testing may be advised to further scrutinize your levels of oxidative stress, vitamin deficiencies, mitochondrial function, etc.) IV NAD+ may be prescribed by us if it’s suitable for your health condition. 

Our IV Lounge has been servicing the Toronto area since 2012 with intravenous therapy and functional medicine treatments, including naturopathic medicine healing, Western medicine, herbal medicine, acupuncture, and holistic nutrition. Next to IV NAD+, we offer drip treatments with vitamin C, glutathione, vitamin B6, mistletoe, folic acid, and more. Keep in mind, safety matters – each IV Lounge session is monitored by our health team of naturopathic doctors, nurse practitioners, and registered nurses. In addition to healthy living and other health interventions (i.e. conventional medicine), NAD IV therapy drips can help support optimal health and function. 

Let’s customize your treatment to target cognitive function, supple skin, and cellular energy! You’re invited to reap the benefits of NAD IV therapy from the Toronto Functional Medicine Centre – leave us a message now to request your initial visit.  

Disclaimer: The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. You should always consult with a health care practitioner before relying on any information in this article or on this website. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of information you have read from the Toronto Functional Medicine Centre website or other affiliate media. 

 

References

Apparoo, Y., Phan, C. W., Kuppusamy, U. R., & Sabaratnam, V. (2022). Ergothioneine and its prospects as an anti-ageing compound. Experimental Gerontology, 170, 111982. https://doi.org/10.1016/j.exger.2022.111982

Bjørklund, G., Shanaida, M., Lysiuk, R., Butnariu, M., Peana, M., Sarac, I., Strus, O., Smetanina, K., & Chirumbolo, S. (2022). Natural Compounds and Products from an Anti-Aging Perspective. Molecules, 27(20). https://doi.org/10.3390/molecules27207084

Borodina I, Kenny LC, McCarthy CM, Paramasivan K, Pretorius E, Roberts TJ, van der Hoek SA, Kell DB. The biology of ergothioneine, an antioxidant nutraceutical. Nutr Res Rev. 2020 Dec;33(2):190-217. doi: 10.1017/S0954422419000301. Epub 2020 Feb 13. PMID: 32051057; PMCID: PMC7653990.

Dhana K, Evans DA, Rajan KB, Bennett DA, Morris MC. Healthy lifestyle and the risk of Alzheimer dementia: Findings from 2 longitudinal studies. Neurology. 2020 Jul 28;95(4):e374-e383. doi: 10.1212/WNL.0000000000009816. Epub 2020 Jun 17. PMID: 32554763; PMCID: PMC7455318.

“Does cellular senescence hold secrets for healthier aging?” from the National Institute on Aging (NIH), posted on July 13, 2021, viewed on July 6, 2024. 

Green AC, Hughes MC, McBride P, Fourtanier A. Factors associated with premature skin aging (photoaging) before the age of 55: a population-based study. Dermatology. 2011 Feb;222(1):74-80. doi: 10.1159/000322623. Epub 2010 Dec 29. PMID: 21196710.

Hofer, S. J., Simon, A. K., Bergmann, M., Eisenberg, T., Kroemer, G., & Madeo, F. (2022). Mechanisms of spermidine-induced autophagy and geroprotection. Nature Aging, 2(12), 1112-1129. https://doi.org/10.1038/s43587-022-00322-9

“How the Aging Brain Affects Thinking” from the National Institute on Aging (NIA), reviewed June 27, 2023, viewed on July 4, 2024. 

Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: A Dietary Antioxidant for Health Promotion. Antioxidants & Redox Signaling, 19(2), 151-162. https://doi.org/10.1089/ars.2012.4901

Li Chen, Liping Zhang, Xujun Ye, Zixin Deng, Changming Zhao, Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis, Protein & Cell, Volume 15, Issue 3, March 2024, Pages 191–206, https://doi.org/10.1093/procel/pwad048

Madeo, F., Carmona-Gutierrez, D., Kepp, O., & Kroemer, G. (2018). Spermidine delays aging in humans. Aging (Albany NY), 10(8), 2209-2211. https://doi.org/10.18632/aging.101517

Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018). Spermidine in health and disease. Science. https://doi.org/aan2788

Naumova, N., Koliada, A., Kuzub, N., & Vaiserman, A. M. (2023). Mitochondrial modulators. Anti-Aging Pharmacology, 193-226. https://doi.org/10.1016/B978-0-12-823679-6.00012-6

Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023). Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients, 15(2). https://doi.org/10.3390/nu15020445

Zhao R, Kou H, Jiang D, Wang F. Exploring the anti-aging effects of fisetin in telomerase-deficient progeria mouse model. PeerJ. 2023 Dec 12;11:e16463. doi: 10.7717/peerj.16463. PMID: 38107570; PMCID: PMC10722989.

Zhou, D., Luo, M., Huang, Y., Saimaiti, A., Shang, A., Gan, Y., & Li, B. (2021). Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases. Oxidative Medicine and Cellular Longevity, 2021. https://doi.org/10.1155/2021/9932218